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Home - Products - Chromatin/Epigenetic - Sirtuin - SRT 3025

SRT 3025

CAS No. 2070015-26-6

SRT 3025 ( SRT3025 )

Catalog No. M13223 CAS No. 2070015-26-6

SRT3025 is a potent, orallu actuve SIRT1 activator that activates wild-type Sirt1 protein.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SRT 3025
  • Note
    Research use only, not for human use.
  • Brief Description
    SRT3025 is a potent, orallu actuve SIRT1 activator that activates wild-type Sirt1 protein.
  • Description
    SRT3025 is a potent, orallu actuve SIRT1 activator that activates wild-type Sirt1 protein, but not the Sirt1 mutant E230K; increases deacetylation of hepatic p65 and skeletal muscle Foxo1 and decreases plasma levels of LDL-cholesterol and total cholesterol and reduced atherosclerosis in vivo.Diabetes Phase 1 Clinical
  • Synonyms
    SRT3025
  • Pathway
    Chromatin/Epigenetic
  • Target
    Sirtuin
  • Recptor
    Sirtuin
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    2070015-26-6
  • Formula Weight
    606.20
  • Molecular Formula
    C31H32ClN5O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 32 mg/mL 52.79 mM
  • SMILES
    COCCCC1=C(N=C(S1)C2=CC=CC=C2)C(=O)NC3=CC=CC=C3C4=NC5=C(S4)N=CC(=C5)CN6CCCC6.Cl
  • Chemical Name
    5-(3-methoxypropyl)-2-phenyl-N-(2-(6-(pyrrolidin-1-ylmethyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)thiazole-4-carboxamide hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Miranda MX, et al. Eur Heart J. 2015 Jan 1;36(1):51-9.
2. Chini CC, et al. Clin Cancer Res. 2016 May 15;22(10):2496-507.
3. Artsi H, et al. Endocrinology. 2014 Sep;155(9):3508-15.L7948:M+M7950
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